Cancer Oncological Care | German Medical Clinics

Cancer Oncological Care

Treatments

Currently, 7.6 million people die from cancer worldwide every year. This number is still increasing every year and Chemotherapy and Radiation alone are not showing promising results apart from the aggressive side effects. Germany the leading country of research for new approaches to fight cancer, provides us with a very effective protocol of different promising treatments with very minimal side effects. In German Medical Clinics we provide our patients with the best treatments of the next generation medicine against cancer and individually each patient receives a protocol to defeat his type of cancer. Our different therapies combine together for a goal to achieve the best remission possible.

At the heart of tumor-based p53 therapy is the p53 gene. Often described as “the guardian of the genome,” p53 plays a central role in blocking the formation of tumors. Improperly functioning p53 genes are known to affect aspects of cancer like aggressiveness, response to treatment and ability to spread to distant sites.

To prevent cancerous cells from dividing uncontrollably, the p53 gene activates proteins that arrest cell division and repair corrupted DNA. In cases where the damage done is irreparable, p53 initiates a process called apoptosis that destroys the tainted cells. The p53 gene can also limit blood flow to tumors which prevents growth and alerts nearby immune cells to attack cancerous cells.

A mutation of the p53 gene is the most common abnormality observed in tumor, especially in Lung cancer and Triple Negative Breast Cancer. After extensive study, researchers determined that the p53 gene is mutated in 50 percent of all cancers and 45 percent of non-small cell lung cancers.

How does p53 Therapy Work?

Preclinical Studies
The results of preclinical studies show that restoration of p53 gene function can activate apoptosis, thus destroying cancerous cells. But replacing cancerous genes with healthy p53 genes is no simple task. To achieve this, doctors have used genetically engineered viruses known as viral vectors. Vehicles for DNA transport are typically infectious, doctors have prevented the viruses from replicating by modifying their genetic code.

Stopping Tumor Growth
Filled with high concentrations of p53, viral vectors are injected directly into malignant tumors. As the virus releases the contained genetic material, the effects of the cancerous genes are reversed. Damaged cells are either destroyed or replaced with p53, which stops the tumor from growing or spreading. To improve treatment effectiveness doctors will sometimes follow up with radiation therapy or a chemotherapy drug such as Cisplatin.

Clinical trial results

Lung cancer clinical trials on p53 therapies have demonstrated notable success. Phase I and II studies proved that this treatment is not only safe, but also far less harmful to healthy cells than chemotherapy.

In one phase II clinical trial conducted on 19 non-small cell lung cancer patients, a p53 therapy called Advexin was given in combination with radiation therapy. After three months, 63 percent of patients had no detectable signs of cancer. This is four times the response expected from radiation treatment alone.

Another Phase II trial P53 gene cancers evaluated INGN-225, a cancer vaccine treated with Advexin immune cells. Among small cell lung cancer patients who were previously given chemotherapy, 66.7 percent treated with INGN-225 experienced a reduction in tumor size greater than 50 percent. Some of these patients were cured of all visible signs of cancer.

What is second generation Gcmaf?

High Dose Second Generation Gc-MAF is produced using our new Patent Pending process which was developed in Japan in collaboration with Dr Hitoshi Hori and Dr Yoshihiro Uto at the University of Tokushima who have been studying GcMAF for over 20 years. Studies on GcMAF began at the University of Tokushima in 1992, after they were introduced to Dr Nobuto Yamamoto's work and a collaboration began...

What makes it different from the first generationWhat the research and doctors say about gcmaf

Second Generation GcMAF is made using a new and improved 2nd generation method of Gc-MAF production which is 10-20 times more concentrated and is more active and stable than other GcMAF that is currently available. Importantly, this much higher concentration GcMAF has been clinically demonstrated to be largely free of any side effects in the great majority of patients and is much more stable because it is resistant to oxidation.

What can gcmaf do

GcMAF can eradicate chronic inflammation and viral infections. It is better than antibiotics in many areas, and 25% successful with Autism, 50% or more with Chronic Herpes, Chronic Acne, Chronic cirrhosis of the liver, Chronic kidney disease, Chronic depression, Colitis, Crohn's, Fibromyalgia, Hepatitis, Herpes, LMBBS, ME/CFS, Osteoporosis, Periodontal disease, Psoriasis and various types of Immune dysfunction including allergies. Research shows GcMAF can halt deterioration in Parkinsons, multiple sclerosis (MS), dementia and ALS, and in its role of immune system regulator, can reverse diseases that attack the immune system like Lupus and Arthritis. And is effective with wound healing. Its successful with tumour cancers, and some others. In addition to rebuilding a depressed immune system, GcMAF:

  1. Inhibits angiogenesis – stops blood supply to tumours
  2. Activates macrophages – phagocytosis and destruction of cancer cells
  3. Apoptosis – suicide of cancer cells
  4. Reverts the cancer cell phenotype to normal (Turns cancer cells into healthy cells)
  5. Reduces the metastatic potential of human cancer cells in culture.
  6. Increases energy production at the mitochondrial level – ME/CFS
  7. Improves human neuronal metabolic activity through cAMP signaling – autism, ME/CFS, MS, ALS
  8. Counters toxic effects including cadmium – ME/CFS
  9. It abolishes neuropathic pain due to neuro-oxidative stress (stress due to the anti-cancer drug oxaliplatin) in the lab.
  10. It increases neuronal connectivity by promoting differentiation and the formation of dendrites and neuritis (autism and ME/CFS, where there is a lack of connectivity between neurons).

Gcmaf and autoimmune diseases

Researchers and practitioners have demonstrated that GcMAF can reverse diseases that attack the immune system such as: chronic inflammation, bacterial and viral infections, chronic herpes, chronic acne, Lyme disease, fibromyalgia osteoporosis, Hodgkin's, Lupus, MS, Parkinson's and remarkably – autism.

What the research and doctors say about Gcmaf?

The GcMAF Conference 2013 showed GcMAF is a far more powerful molecule than thought, both in terms of the science, and doctors' results. In stage 4 cancer, some doctors who use the full protocol, listed on "Treatment Strategies," are saving every patient (if they have not had chemotherapy.) Success can be achieved with all tumour cancers including breast, lung, prostate, pancreatic and melanoma.

Administration of these activated T lymphocytes (TILs) demonstrates significant clinical activity in some patients with several type of cancer, making it a useful adoptive immunotherapy. In this method not only T lymphocytes are activated, but also Hyper T cells and NK cells. Hyper T cells have more widely specific antigenicity for antigens expressed by autologous tumor cells, high ability of proliferation and keep their activity for long periods in vivo.6 Therefore, expansion of Hyper T cells promises to be a suitable and important factor of adoptive immunotherapy against cancer. NK cells represent a unique subset of lymphocytes, distinct from T lymphocytes. They contribute essential immune systems to host anti-microbial and anti-tumor immunity against cancer or viral infection without the requirement for prior immune sensitization of the host.7 NK cells function as promising effectors for adoptive immunotherapy against cancer.

Is a very unique cancer (tumor) vaccine derived from tissue fragments from the patient's own cancer tumor. Immune cells are trained in the lab to kill your specific type of cancer, and kill the targeted tumor cells in a very specific manner.

The immune system helps people to stay healthy by recognizing bacteria and viruses as well as cancer cells as noxious and by killing these. It has been known for quite some time that for the recognition of foreign materials (antigens) the body needs antigen presenting cells. These antigen presenting cells alert the immune system to the intruder and activate further immune cells that fight the antigen by various means. Amongst the most important antigen presenting cells are the dendritic cells. They have tree like arms (Greek: Dendron=tree) with which they search the lymphatic fluids for foreign materials. Cancer cells differ from healthy cells. This difference is harnessed by immunotherapy by fighting the cancer with the body’s own immune system.

It is known, that tumors show the accumulation of several genetic modifications, thus providing cancer cells with the selective growth advantage to initiate expansion. Now, sophisticated high-throughput technologies enable the identification of these mutated genes in cancers, leading to a potent targeted immunotherapy in the form of an antigen-specific peptide vaccine.

First, a tumor antigen specific assay is performed, where blood/tissue will be analyzed for tumor associated peptides that can be used as treatment targets. Overall, about 20 therapeutic relevant tumor-associated-antigens are analyzed for subsequent peptide vaccination, which will be given subcutaneously together with an adjuvant to enhance the immune response. Based on ongoing clinical studies, this new vaccine approach will revolutionize the treatment of almost every kind of cancer.

The development of checkpoint blocking antibodies, such as those directed against cytotoxic T-lymphocyte antigen 4 (CTLA-4) and programmed death 1 receptor (PD-1), has shown to be one of the most promising approaches to activating therapeutic antitumor immunity in the treatment of an expanding list of malignancies. Immune checkpoints refer to a wide range of inhibitory pathways that are crucial for maintaining self-tolerance and modulation of immune responses in order to minimize tissue damage. But it is now known that tumors modify certain immune-checkpoint pathways as a major mechanism of immune resistance, particularly against T cells that are specific for recognition and targeting of tumor antigens. Many of these regulatory immune checkpoints can now be blocked by antibodies or modulated by recombinant forms of ligands and receptors.

Curcumin , or turmeric, is best known by many people as a spice used in the Asian cuisine. Curcuminoids are polyphenolic compounds and are responsible for the yellow color of turmeric- curcumin is the principal curcuminoid in turmeric.
Interestingly, studies have shown that in countries with high curcumin consumption, rates of certain types of cancer are low. Early trials have shown great promise, one trial looked at the effect of curcumin in patients with pre-cancerous changes in different organs, and another study combined curcumin with chemotherapy to treat bowel cancer cells in vitro, which showed that this combination was more effective in killing malignant cells than chemotherapy alone. Other in vitro studies showed also cytotoxicity against breast cancer, bowel cancer, stomach cancer and skin cancer cells. Curcumin is also used for its antioxidant properties as high doses injected intravenously.

DCA

Mitochondria are often referred to as the ‘power stations’ in our cells, since they generate energy for our cells – this energy is generated by breaking down glucose, in a process known as the Krebs cycle, which takes place in the mitochondria.

Mitochondria can also initiate cell death (apoptosis) if the cell is not healthy, which inhibits malignant growth. But cancer cells can evade this cell death by switching off their mitochondria, and using other means to produce energy, which take place outside the mitochondria. Studies showed that addition of DCA, dichloroacetate, to cancer cells turns the mitochondria back on again, thus leading to death of cancer cells. It was also shown, that DCA did not affect healthy cells, since their mitochondria were functioning normally. DCA was also shown to enhance the effects of radiation, and has already been used in patients with glioblastoma.

TBL-12 is a sea cucumber extract, which has been shown to have cytotoxic properties against cancer cells in vitro. In cell culture models of human myeloma cells, TBL12 effectively reduced growth of myeloma cells in a dose-dependent manner with minimal toxicity. It is thought to induce programmed cell death.

TBL-12 is currently involved in a number of clinical trials, e.g. in the treatment of Multiple Myeloma. But there are many more studies planned to target other types of cancers, including solid tumors, and immune system related diseases.

Homeopathy is an alternative treatment approach that was developed in Germany, by Samuel Christian Hahnemann (1755-1843), a German physician. Hahnemann developed the principle of homeopathy that “like cures like (“similia similibus curentur” ), meaning that a disease can be cured by a substance or drug that causes similar symptoms in healthy people. The story behind this discovery is, that Hahnemann took a small amount of a certain bark (chonchona), which contains quinine, a drug used in the treatment of malaria, and then developed the symptoms of malaria himself.

Homeopathy also respects the law of minimum dose, meaning that the lower the dose of the medication, the greater its power. Homeopathic remedies are derived from substances that come from plants, minerals, or even animals and are created using a process of homeopathic dilution.

High dose Vitamin C, alpha lipoic acid, selenium, B complex
Vitamin C, also known as ascorbic acid, is an essential vitamin. It is a potent antioxidant which helps to protect against free radical damage to our proteins, fats, carbohydrates, DNA and RNA. Vitamin C is used to boost the immune system and cleanse the body.

Selenium is a trace mineral that is known for its antioxidant and antiinflammatory properties. It plays an important role in the antioxidant defense system of the cell and is therefore used for its immune-supportive effects.

Zinc - Zinc is an important trace mineral that is also crucial for a proper working immune system. Zinc is required for cellular metabolism, and plays a pivotal role in protein and DNA synthesis, wound healing, and cell division.

L-ornithine aspartate is an amino acid that improves liver detoxification, and is already widely used in clinics to treat patients with liver cirrhosis and hepatic encephalopathy, as this amino acid reduces ammonia levels by increasing hepatic ammonia disposal and its peripheral metabolism.

Alpha lipoic acid is a potent antioxidant that is not only used to boost the immune system, but also for patients that suffer from periphereal neuropathy, a common side effect from chemotherepeutic drugs, or a symptom often presented in diabetes. It also used in the treatment of cancer, infections, and neurological diseases and as a chelator.

It increases the amount of oxygen to the body through the introduction of ozone into the body. Various methods have been suggested on the method of introducing the ozone into the body, and the purported benefits of this therapy include the treatment of various diseases including cancer, AIDS, multiple sclerosis, among others. Infected cells in the body cannot live in high oxygen levels. When ozone goes into the blood, all the infected cells cannot bare the amount of oxygen and their cell membranes burst directly. However, the amount of oxygen supports the healthy cells and increases their energy.

Local hyperthermia (or thermal ablation) is used to heat a small area like a tumor. Very high temperatures are used to kill the cancer cells by coagulating the proteins in them and destroying nearby blood vessels. In effect, this cooks the area that is exposed to the heat.

Photodynamic therapy (PDT) is a form of phototherapy using nontoxic light-sensitive drugs (called a photosensitizer, or simply sensitizer for short) that are exposed selectively to light, whereupon they cause targeted malignant and other diseased cells to die.

In a similar way, Sonodynamic therapy (SDT) uses therapeutic ultrasound instead of light to activate these sensitizer compounds, to provide much deeper penetration to the target cancer cells in the body.

Benefits of PDT and SDT Therapy

  1. Sensitizers are non-toxic and safe to use repeatedly as there is no total dose limitation.
  2. The treatment is targeted to primarily to the tumor with minimal effect on healthy tissue.
  3. PDT and SDT therapy does not suppress immune function. In fact quite the opposite is true. PDT and SDT is a perfect complement to immunotherapies.
  4. Vaccine-like response from immunogenic cancer cell necrosis and cancer-immune response.

Cyberknife is one of the most advanced and unique form of radiosurgery that uses highly sophisticated computer technology to deliver radiation with extreme precision to tumors anywhere in the body, without the use of uncomfortable screws or frames to immobilize patients during the procedure.

During Cyberknife treatment, radiation beams target the tumor while sparing the surrounding healthy tissue. Unlike surgery, tumors are not removed, but destroyed by a precise dose of radiation. No incision is made. Another major advantage is that the radiation beams adjust in real-time to a patient's breathing cycle, which is important, as some tumors keep moving during treatment application. Cyberknife is a highly effective non-invasive alternative to surgery in the treatment of certain cancers.

TACE is a combination of transarterial embolization and regional chemotherapy with the major advantage that chemotherapeutic drugs remain in the tumor tissue for a longer period at a higher concentration, while the embolotherapy interrupts the arterial blood flow to the tumor and inhibits washout of the injected chemotherapeutic drugs. TACE has been widely used in liver cancer.